AROA Products
Endoform™
Overview
Endoform™ Antimicrobial Restorative Bioscaffold and Endoform™ Natural Restorative Bioscaffold are unique extracellular matrix (ECM) products for the management of acute and chronic wounds.
Endoform™ products support all phases of wound healing and are appropriate for use early in wound management to restore protease balance and advance healing to the proliferative phase.(1)
Endoform™ products:
- Provide a natural porous ECM bioscaffold for rapid cell infiltration(2)
- Contain more than 150 ECM proteins known to be important in wound healing(3)
- Contain residual vascular channels to support the establishment of new vasculature(4)
- Can indicate the presence or absence of proteases and help restore protease balance and guide re-application(5)
- Can be used by any wound care provider from day 1(1)
Endoform™ Antimicrobial Restorative Bioscaffold contains 0.3% ionic silver, appropriate for use in early acute and chronic wound management where there is an elevated risk of infection.
- Provides broad spectrum antimicrobial activity for up to 7 days*(6)
- Prevents biofilm formation(6)
- Is non-cytotoxic to dermal cells(6)
*Endoform™ Antimicrobial contains 0.3% ionic silver to protect the dressing from microbial colonization
Ionic silver has been included in Endoform™ Antimicrobial to protect the device from microbial contamination. Reduction in colonization or microbial growth on the device has not been shown to correlate with a reduction in infections in patients. Clinical studies to evaluate reduction in infection have not been performed.
How It Works
Endoform™ Antimicrobial and Endoform™ Natural Restorative Bioscaffold products work in all phases of healing to stabilize, correct, build and organize tissue.
Endoform™ products are made from AROA ECM™ technology and contain more than 150 extracellular matrix (ECM) proteins that enable it to interact with patient’s cells throughout all phases of healing.(1, 2) Endoform™ products are 85% collagen and 15% important secondary molecules, including structural and adhesion proteins, and glycosaminoglycans (GAGs).(1) Endoform™ products only contain components found in tissue extracellular matrix.
During the inflammatory phase, chronic wounds are characterized by elevated wound proteases that limit healing by digesting important dermal proteins.(3) Endoform™ products can help indicate the presence or absence of proteases and restores protease balance.(4, 5) If Endoform™ products are not visible in the wound bed at the time of reapplication, this can indicate elevated wound protease activity. However, if Endoform™ is visible, this can indicate that protease balance has been restored.
Endoform™ products also contain residual vascular channels that facilitate the rapid establishment of a dense capillary network by supporting migrating endothelial cells to establish new vasculature and a robust blood supply to help build new tissue.(6) This process is termed angioconduction.
1. S. Lun, S.M. Irvine, K.D. Johnson, N.J. Fisher, E.W. Floden, L. Negron, S.G. Dempsey, R.J. McLaughlin, M. Vasudevamurthy, B.R. Ward, B.C. May, A functional extracellular matrix biomaterial derived from ovine forestomach, Biomaterials 31(16) (2010) 4517-29. 2. S.G. Dempsey, C.H. Miller, R.C. Hill, K.C. Hansen, B.C.H. May, Functional Insights from the Proteomic Inventory of Ovine Forestomach Matrix, J Proteome Res 18(4) (2019) 1657-1668. 3. R. Lobmann, A. Ambrosch, G. Schultz, K. Waldmann, S. Schiweck, H. Lehnert, Expression of matrix-metalloproteinases and their inhibitors in the wounds of diabetic and non-diabetic patients, Diabetologia 45(7) (2002) 1011-6. 4. G.A. Bohn, Endoform: A Simple Tool to Assess Wound Proteases, Wound Management and Prevention 65(3) (2019) 18-20. 5. L. Negron, S. Lun, B.C.H. May, Ovine forestomach matrix biomaterial is a broad spectrum inhibitor of matrix metalloproteinases and neutrophil elastase, Int Wound J 11(4) (2012) 392-397. 6. Smith MJ, Dempsey SG, Veale RW, et al. Further structural characterization of ovine forestomach matrix and multi-layered extracellular matrix composites for soft tissue repair. Journal of Biomaterials Applications. 2022;36(6):996-1010. doi:10.1177/08853282211045770
Indications
Endoform™ Antimicrobial Restorative Bioscaffold and Endoform™ Natural Restorative Bioscaffold products are indicated for the management of acute and chronic wounds including:
- Partial and full-thickness wounds
- Pressure ulcers
- Venous ulcers
- Diabetic ulcers
- Chronic vascular ulcers
- Tunneled/undermined wounds
- Surgical wounds (donor sites, grafts, post Moh’s surgery, post laser surgery, podiatric, wound dehiscence)
- Traumatic wounds (abrasions, lacerations, second-degree burns, and skin tears)
- Draining wounds
Myriad Matrix™
Overview
Myriad Matrix™ is an engineered extracellular matrix (ECM) for soft tissue repair, reinforcement and complex wounds.
Myriad Matrix™ has been specifically designed to help maximize tissue repair while providing versatility and adaptability across a wide range of surgical applications.
Myriad Matrix™ is designed to be easily customizable for a wide range of anatomical sites and surgical needs and can be used in both implantation and dermal repair.
- Myriad Matrix™ is strong, soft, drapable, and conforming
- Myriad Matrix™ rehydrates quickly and is easy to cut, suture or staple
- Myriad Matrix™ helps to achieve surgical mastery in routine and challenging repair and reinforcement procedures
How It Works
Myriad Matrix™ devices contain the natural porous structure of AROA ECM™, engineered with interstitial perforations to enable cell infiltration to facilitate rapid 
Fast absorption of blood & cells accelerates host cell infiltration
The rapid absorption of blood and blood components forms a reservoir of biologically important cells and cell components to help kick-start the tissue repair process.(1-4) Fibroblast, endothelial and immune cells infiltrate the entire matrix, build new tissue and over time Myriad Matrix™ is completely remodeled by the patient’s own tissue.(3, 4)
Delivers biology known to be important in healing
Myriad Matrix™ retains the authentic structure and complexity of natural tissue ECM and provides biological cues to aid the repair process.(5) Myriad Matrix™ contains more than 150 ECM proteins, including collagen and other secondary molecules that exist in tissue and aid the healing process.(6)
Contains residual vascular channels
Angioconduction is the structural effect of vascular channels on endothelial cells to support blood vessel development. Myriad Matrix™ promotes angioconduction via the residual vascular channels within the Aroa ECM™ source biomaterial, helping to facilitate the rapid establishment of a dense capillary network.(7, 8)
Myriad Matrix™ is indicated for implantation to reinforce soft tissue where weakness exists in patients requiring soft tissue repair or reinforcement in plastic and reconstructive surgery, or for management of the following wounds:
- Partial and full thickness wounds
- Pressure ulcers
- Venous ulcers
- Diabetic ulcers
- Chronic vascular ulcers
- Tunneled/ undermined wounds
- Surgical wounds (donor sites, grafts, post Moh’s surgery, post laser surgery, podiatric, wound dehiscence)
- Trauma wounds (abrasions, lacerations, second-degree burns, and skin tears)
- Draining wounds
Myriad Morcells™
Overview
Myriad Morcells™ is a morcellized (powdered) format of Myriad Matrix™ for soft tissue repair and complex wounds.
Myriad Morcells™ delivers a bolus of biologically important extracellular matrix (ECM) proteins that help kick start healing.
- The morcellized format of Myriad Morcells™ increases the AROA ECM™ surface area to maximize delivery
- Myriad Morcells™ easily conforms to optimize contact with irregular wound beds
- Myriad Morcells™ can also be conveniently hydrated in the tray
How It Works
Myriad Morcells™ delivers complex biology known to be important in healing
Myriad Morcells™ utilizes the AROA ECM™ platform technology which contains more than 150 naturally occurring ECM proteins known to be important in healing.(1)
The morcellized format increases the surface area to maximize delivery of the biology.
Used in combination, Myriad Morcells™ works synergistically with Myriad Matrix™
The biology in Myriad Morcells™ acts to further accelerate cell infiltration into the Myriad Matrix™.
Myriad Matrix™ provides the structure and residual vascular channels that speeds the establishment of new tissue.
Use of Myriad Matrix™ has been shown to result in organized, highly vascular, functional tissue.(2,3)
ndications
Myriad Morcells™ are indicated for use in the management of the following wounds: 
- Partial and full thickness wounds
- Pressure ulcers
- Venous ulcers
- Diabetic ulcers
- Chronic vascular ulcers
- Tunneled/undermined wounds
- Surgical wounds (donor sites, grafts, post Moh’s surgery, post laser surgery, podiatric, wound dehiscence)
- Trauma wounds (abrasions, lacerations, partial-thickness burns, and skin tears)
- Draining wounds
Myriad Morcells Fine™
Overview
Myriad Morcells Fine™ delivers a bolus of biologically important extracellular matrix (ECM) proteins to help kick start and sustain healing.
- The morcellized format increases the AROA ECM™ surface area to maximize delivery of important ECM proteins
- Myriad Morcells Fine™ easily conforms to optimize contact with irregular wound beds
- Myriad Morcells Fine™ can also be conveniently hydrated in the tray
How It Works
Myriad Morcells™ delivers complex biology known to be important in healing
Myriad Morcells™ utilizes the AROA ECM™ platform technology which contains more than 150 naturally occurring ECM proteins known to be important in healing.(1)
The morcellized format increases the surface area to maximize delivery of the biology.
Used in combination, Myriad Morcells™ works synergistically with Myriad Matrix™
The biology in Myriad Morcells™ acts to further accelerate cell infiltration into the Myriad Matrix™.
Myriad Matrix™ provides the structure and residual vascular channels that speeds the establishment of new tissue.
Use of Myriad Matrix™ has been shown to result in organized, highly vascular, functional tissue.(2,3)
Indications
Myriad Morcells Fine™ are indicated for use in the management of the following wounds: 
- Partial and full-thickness wounds
- Pressure ulcers
- Venous ulcers
- Diabetic ulcers
- Chronic vascular ulcers
- Tunneled/undermined wounds
- Surgical wounds (donor sites, grafts, post-Moh’s surgery, post laser surgery, podiatric, wound dehiscence)
- Trauma wounds (abrasions, lacerations, partial-thickness burns, and skin tears)
- Draining wounds
Symphony™
Overview
What is Symphony ?
Symphony is a combination cellular and tissue product (CTP*), comprising multiple layers of AROA ECM™ with hyaluronic acid. Symphony brings together the regenerative properties of extracellular matrix (ECM) technology and hyaluronic acid to help advance wound closure(1).
- Facilitates the regeneration of functional tissue in complex wounds(2)
- Provides a synergistic combination of AROA ECM™ and hyaluronic acid(1)
- Offers simple hydration, easy handling, and conforms well to the wound bed(3)
How It Works
Symphony facilitates the regeneration of functional tissue in complex wounds(1). It does this by providing a synergistic combination of AROA ECM™ and hyaluronic acid(2).
ndications
Symphony is indicated for use in the management of the following wounds:
- Partial and full-thickness wounds
- Pressure ulcers
- Venous ulcers
- Diabetic ulcers
- Chronic vascular ulcers
- Tunneled/Undermined wounds
- Surgical wounds (donor sites/grafts, post-Moh’s surgery, post-laser surgery, podiatric, wound dehiscence)
- Trauma wounds
(abrasions, lacerations, second-degree burns, and skin tears) - Draining wounds
